Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059154 | 0.86 | POLB (0.40) | POLBL3MBTL1KDM4EHRH4CHRM3 | |
| SCHEMBL9537404 | 0.84 | SIGMAR1 (0.39) | L3MBTL1CHRM3CHEK1KMT2AMAPT | |
| SCHEMBL9059786 | 0.80 | SIGMAR1 (0.46) | POLBL3MBTL1KDM4EKMT2AMAPT | |
| SCHEMBL9059413 | 0.77 | SIGMAR1 (0.42) | KDM1AMAOAMAOBL3MBTL1KMT2A | |
| SCHEMBL9059335 | 0.76 | MET (0.39) | POLBL3MBTL1KDM4EHRH4CHRM3 | |
| SCHEMBL9059945 | 0.76 | POLB (0.38) | POLBKDM1AMAOAMAOBL3MBTL1 | |
| SCHEMBL9059864 | 0.75 | SIGMAR1 (0.40) | KDM1AMAOAMAOBL3MBTL1CHRM3 | |
| SCHEMBL9537980 | 0.74 | SIGMAR1 (0.47) | POLBKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL8395262 | 0.73 | SIGMAR1 (0.50) | POLBKDM4EKMT2ANPC1MAPT | |
| SCHEMBL9059169 | 0.72 | POLB (0.39) | POLBL3MBTL1KDM4ECHRM3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536151-A1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM. | BOOTS CO PLC (GB) | 1993-04-14 | — | — | EP | disclosed |