Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 6/20 | 0.60 |
| ▸ | GRM6 | O15303 | 6/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.60 |
| ▸ | PTPRC | P08575 | 1/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.49 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | PGK2 | P07205 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398444 | 0.83 | GRM4 (0.60) | GRM8GRM6GRM4PTPRCPGK1 | |
| SCHEMBL8397453 | 0.81 | GRM8 (0.60) | GRM8GRM6GRM4PTPRCPGK1 | |
| SCHEMBL10422678 | 0.79 | VCAM1 (0.53) | GRM8GRM6GRM4VCAM1MAPT | |
| SCHEMBL9523948 | 0.79 | EPAS1 (0.53) | GRM8GRM6GRM4VCAM1MAPT | |
| SCHEMBL8396055 | 0.78 | FFAR1 (0.61) | GRM8GRM6GRM4PTPRCPTPN5 | |
| (3,4-Dichlorophenyl)(Hydroxy)Methylphosphonic Acid SCHEMBL11292374 | 0.78 | PTPN5 (0.63) | PGK1PGK2PTPN5 | |
| SCHEMBL8398394 | 0.78 | GRM8 (0.63) | GRM8GRM6GRM4PTPRCGRM7 | |
| SCHEMBL1987819 | 0.78 | GRM8 (0.53) | GRM8GRM6GRM4VCAM1MAPT | |
| SCHEMBL241620 | 0.78 | GRM8 (0.53) | GRM8GRM6GRM4VCAM1MAPT | |
| SCHEMBL12727085 | 0.78 | GRM8 (0.53) | GRM8GRM6GRM4VCAM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994563-A | THIOPHENE DERIVATIVES, IMMUNOSUPPRESSANTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-11-30 | — | — | US | disclosed |