Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 10/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 10/20 | 0.60 |
| ▸ | GRM6 | O15303 | 8/20 | 0.60 |
| ▸ | PTPRC | P08575 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | PGK2 | P07205 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398444 | 0.83 | GRM4 (0.60) | GRM8GRM4GRM6PTPRCTSHR | |
| SCHEMBL8395379 | 0.81 | GRM8 (0.60) | GRM8GRM4GRM6PTPRCPGK1 | |
| SCHEMBL8398394 | 0.81 | GRM8 (0.63) | GRM8GRM4GRM6PTPRCTSHR | |
| SCHEMBL4434685 | 0.80 | ALDH1A1 (0.53) | GRM8GRM4GRM6TSHRALDH1A1 | |
| SCHEMBL11087405 | 0.78 | PGK1 (0.59) | GRM8GRM4GRM6PTPRCPGK1 | |
| SCHEMBL2756243 | 0.78 | GRM8 (0.53) | GRM8GRM4GRM6TSHRALDH1A1 | |
| SCHEMBL13774889 | 0.76 | GRM8 (1.00) | GRM8GRM4GRM6GRM7 | |
| SCHEMBL2436243 | 0.76 | TSHR (0.56) | GRM8GRM4GRM6TSHRALDH1A1 | |
| SCHEMBL12348008 | 0.76 | GRM8 (0.49) | GRM8GRM4GRM6TSHRALDH1A1 | |
| SCHEMBL14997909 | 0.75 | GRM8 (0.48) | GRM8GRM4GRM6TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994563-A | THIOPHENE DERIVATIVES, IMMUNOSUPPRESSANTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-11-30 | — | — | US | disclosed |