Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926779 | 0.86 | HRH1 (0.41) | HRH1CYP2D6CYP2C19KDM4ETDP1 | |
| SCHEMBL13612608 | 0.86 | HRH1 (0.46) | HRH1CYP2D6CYP2C19KDM4EHSD11B1 | |
| SCHEMBL10961176 | 0.84 | CYP2D6 (0.41) | HRH1CYP2D6CYP2C19KDM4ETDP1 | |
| SCHEMBL29322718 | 0.82 | MAPK1 (0.40) | CYP2D6CYP2C19KDM4ETDP1MAPK1 | |
| SCHEMBL8583237 | 0.82 | ALDH1A1 (0.36) | HRH1CYP2D6CYP2C19KDM4ETDP1 | |
| SCHEMBL11569854 | 0.82 | — | — | |
| SCHEMBL10960846 | 0.79 | HRH3 (0.39) | HRH1KDM4EHSD11B1MAPK1RAB9A | |
| SCHEMBL10930283 | 0.78 | HSD11B1 (0.42) | KDM4EHSD11B1MAPK1RAB9AALDH1A1 | |
| SCHEMBL329951 | 0.77 | LMNA (0.32) | HRH1CYP2D6CYP2C19KDM4ETDP1 | |
| SCHEMBL11572427 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2901297-B2 | — | — | 1999-06-07 | — | — | JP | claimed |
| EP-0378657-A1 | OXAZOLIDINONE PENETRATION ENHANCING COMPOUNDS. | RAJADHYAKSHA VITHAL J | 1990-07-25 | — | — | EP | claimed |
| WO-1990000407-A1 | OXAZOLIDINONE PENETRATION ENHANCING COMPOUNDS | RAJADHYAKSHA VITHAL J (US) | 1990-01-25 | — | — | WO | claimed |