Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.94 |
| ▸ | HEXA | P06865 | 14/20 | 0.90 |
| ▸ | HEXB | P07686 | 14/20 | 0.90 |
| ▸ | OGA | O60502 | 1/20 | 0.90 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elinafide SCHEMBL19067 | 0.97 | SIRT1 (1.00) | SIRT1HEXAHEXBOGAMEN1 | |
| Elinafide SCHEMBL29441732 | 0.97 | SIRT1 (1.00) | SIRT1HEXAHEXBOGAMEN1 | |
| Elinafide SCHEMBL6256967 | 0.97 | SIRT1 (1.00) | SIRT1HEXAHEXBOGAMEN1 | |
| SCHEMBL4408773 | 0.95 | HEXA (1.00) | SIRT1HEXAHEXBOGA | |
| SCHEMBL31011151 | 0.95 | HEXA (1.00) | SIRT1HEXAHEXBOGA | |
| SCHEMBL13909963 | 0.94 | SIRT1 (0.94) | SIRT1HEXAHEXBOGAMEN1 | |
| SCHEMBL3292141 | 0.93 | SIRT1 (0.81) | SIRT1HEXAHEXBOGA | |
| Bnipspd SCHEMBL13909975 | 0.92 | SIRT1 (0.91) | SIRT1HEXAHEXBOGAMEN1 | |
| Bnipdadec SCHEMBL13909967 | 0.92 | SIRT1 (0.97) | SIRT1HEXAHEXBOGAMEN1 | |
| Bnipdanon SCHEMBL13909969 | 0.92 | SIRT1 (0.97) | SIRT1HEXAHEXBOGAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981753-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-09 | — | — | US | disclosed |
| EP-0714387-B1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AG (DE) | 1998-05-27 | — | — | EP | disclosed |
| US-5616589-A | Bis-naphthalimides for the treatment of cancer | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-01 | — | — | US | disclosed |
| EP-0714387-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005365-A1 | NEW BIS-NAPHTHALIMIDES FOR THE TREATMENT OF CANCER | BASF AKTIENGESELLSCHAFT (DE) | 1995-02-23 | — | — | WO | disclosed |