Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299788 | 0.95 | TLR8 (0.53) | TLR8CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1099019 | 0.81 | CACNA1C (0.51) | ALDH1A1KDM4ENPSR1XIAPBIRC2 | |
| SCHEMBL516003 | 0.81 | TLR8 (0.51) | TLR8CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11721783 | 0.80 | TLR8 (0.51) | TLR8CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16790977 | 0.79 | HRH3 (0.43) | ALDH1A1TSHRKDM4EHRH3XIAP | |
| SCHEMBL6469127 | 0.78 | TLR8 (0.53) | TLR8TLR7ALDH1A1LMNATP53 | |
| SCHEMBL22011153 | 0.78 | HRH4 (0.40) | TLR8ALDH1A1KDM4EHRH3XIAP | |
| SCHEMBL1099121 | 0.78 | KDM4E (0.46) | ALDH1A1LMNAMAPK1KDM4EXIAP | |
| Hydrochloric Acid SCHEMBL16766687 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4EHRH3XIAP | |
| SCHEMBL3222006 | 0.77 | HRH3 (0.59) | ALDH1A1HRH3XIAPBIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939553-A | Process for preparing pyridine-2,6-diamines | AKZO NOBEL N.V. (NL) | 1999-08-17 | — | — | US | disclosed |
| EP-0825985-B1 | A PROCESS FOR PREPARING PYRIDINE-2,6-DIAMINES | AKZO NOBEL NV (NL) | 1999-05-26 | — | — | EP | disclosed |
| EP-0825985-A1 | A PROCESS FOR PREPARING PYRIDINE-2,6-DIAMINES | Akzo Nobel N.V. (NL) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036607-A1 | A PROCESS FOR PREPARING PYRIDINE-2,6-DIAMINES | AKZO NOBEL N.V. (NL) | 1996-11-21 | — | — | WO | disclosed |