Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392594 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2APLAU | |
| SCHEMBL8394066 | 0.98 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1KMT2APLAU | |
| SCHEMBL8391528 | 0.95 | ACHE (0.42) | ALDH1A1KDM4EMEN1KMT2APLAU | |
| SCHEMBL8394593 | 0.91 | HTR6 (0.39) | ALDH1A1KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL12391278 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL14779667 | 0.72 | ALDH1A1 (0.45) | ALDH1A1KDM4EMEN1KMT2AIDO1 | |
| SCHEMBL1531671 | 0.72 | EPHX2 (0.45) | ALDH1A1MEN1KMT2APLAUHPN | |
| SCHEMBL10688944 | 0.71 | GAA (0.51) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL2067991 | 0.70 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2APLAU | |
| SCHEMBL14779621 | 0.70 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |