SCHEMBL8397144

SCHEMBL8397144

ClP(Oc1ccc2ccccc2c1)Oc1ccc2ccccc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.52
CYP1A2 P05177 2/20 0.52
AGXT P21549 2/20 0.47
TDP1 Q9NUW8 3/20 0.45
KDM4E B2RXH2 1/20 0.45
MAPK1 P28482 1/20 0.45
ALOX5 P09917 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA9 Q16790 2/20 0.44
GAA P10253 1/20 0.42
RCE1 Q9Y256 1/20 0.42
GPR84 Q9NQS5 1/20 0.42
MAPT P10636 2/20 0.41
KMT2A Q03164 2/20 0.41
PTPN7 P35236 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.41
HSD17B10 Q99714 2/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27619363 0.86 CYP2A6 (0.52) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL3960261 0.81 CYP2A6 (0.56) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL10946368 0.77 CYP2A6 (0.52) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL11587475 0.77 CYP1A2 (0.52) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL4238279 0.77 CYP1A2 (0.52) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL28167104 0.75 CYP1A2 (0.45) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL3500443 0.75 CYP2A6 (0.67) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL10946372 0.74 AGXT (0.48) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL11701826 0.74 CYP2A6 (0.48) CYP2A6CYP1A2AGXTTDP1KDM4E
SCHEMBL16705219 0.73 CYP2A6 (0.58) CYP2A6CYP1A2AGXTTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2277623-A2 Polymeric phosphorus-containing compositions and their use in hydrocyanation, unsaturated nitrile isomerization and hydroformylation reactions INVISTA Technologies S.à.r.l. (CH) 2011-01-26 EP disclosed
EP-1448298-B1 POLYMERIC PHOSPHORUS-CONTAINING COMPOSITIONS AND THEIR USE IN HYDROCYANATION, UNSATURATED NITRILE ISOMERIZATION AND HYDROFORMYLATION REACTIONS INVISTA TECH SARL (CH) 2010-09-22 EP disclosed
EP-1586598-B1 Process for preparation of polymeric, phosphorus-containing compositions INVISTA TECH SARL (CH) 2009-09-09 EP disclosed
EP-1905511-A2 Phosphorus-containing compositions and their use in hydrocyanation, isomerization and hydroformylation reactions INVISTA Technologies S.à.r.l. (CH) 2008-04-02 EP disclosed
US-5910600-A Bisphosphite compound, process for its production and hydroformylation process employing the bisphosphite compound MITSUBISHI CHEMICAL CORPORATION (JP) 1999-06-08 US disclosed