Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 9/20 | 0.35 |
| ▸ | MME | P08473 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | FSHR | P23945 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840167 | 0.90 | MLNR (0.39) | AGTR1MMESMN1; SMN2 | |
| SCHEMBL839993 | 0.90 | SLC6A4 (0.37) | AGTR1MMEMMP3 | |
| SCHEMBL841570 | 0.89 | SLC6A4 (0.42) | AGTR1MME | |
| SCHEMBL840844 | 0.88 | AGTR1 (0.41) | AGTR1MME | |
| SCHEMBL839522 | 0.88 | AGTR1 (0.38) | AGTR1MME | |
| SCHEMBL840456 | 0.88 | AGTR1 (0.41) | AGTR1MME | |
| SCHEMBL839257 | 0.87 | AGTR1 (0.37) | AGTR1MMEFSHR | |
| SCHEMBL839995 | 0.87 | AGTR1 (0.39) | AGTR1MME | |
| SCHEMBL839172 | 0.87 | AGTR1 (0.37) | AGTR1MME | |
| SCHEMBL840597 | 0.86 | AGTR1 (0.43) | AGTR1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |