Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 5/20 | 0.39 |
| ▸ | MME | P08473 | 10/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839718 | 0.90 | BACE1 (0.35) | MMEAGTR1SMN1; SMN2 | |
| SCHEMBL839522 | 0.90 | AGTR1 (0.38) | MMEAGTR1 | |
| SCHEMBL839993 | 0.88 | SLC6A4 (0.37) | MMEAGTR1 | |
| SCHEMBL839172 | 0.88 | AGTR1 (0.37) | MMEAGTR1MEN1KMT2A | |
| SCHEMBL840844 | 0.88 | AGTR1 (0.41) | MMEAGTR1 | |
| SCHEMBL841570 | 0.88 | SLC6A4 (0.42) | MMEAGTR1 | |
| SCHEMBL840456 | 0.87 | AGTR1 (0.41) | MMEAGTR1 | |
| SCHEMBL839257 | 0.87 | AGTR1 (0.37) | MMEAGTR1 | |
| SCHEMBL839995 | 0.87 | AGTR1 (0.39) | MMEAGTR1ALDH1A1TSHRMEN1 | |
| SCHEMBL841048 | 0.87 | HDAC1 (0.40) | MMEAGTR1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |