Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.36 |
| ▸ | MME | P08473 | 9/20 | 0.36 |
| ▸ | HTR5A | P47898 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839257 | 0.97 | AGTR1 (0.37) | SLC6A4AGTR1MMEHTR5AHTR1A | |
| SCHEMBL841570 | 0.94 | SLC6A4 (0.42) | SLC6A4AGTR1MMEHTR5AHTR1A | |
| SCHEMBL839718 | 0.90 | BACE1 (0.35) | AGTR1MMEMMP3 | |
| SCHEMBL839269 | 0.89 | AGTR1 (0.40) | AGTR1MMELTB4R2 | |
| SCHEMBL840167 | 0.88 | MLNR (0.39) | AGTR1MME | |
| SCHEMBL839172 | 0.88 | AGTR1 (0.37) | AGTR1MME | |
| SCHEMBL839949 | 0.88 | AGTR1 (0.41) | AGTR1MMELTB4R2 | |
| SCHEMBL839252 | 0.88 | AGTR1 (0.41) | AGTR1MMELTB4R2 | |
| SCHEMBL859394 | 0.88 | AGTR1 (0.41) | AGTR1MMELTB4R2 | |
| SCHEMBL841053 | 0.87 | REN (0.42) | AGTR1MMELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |