Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8400124 | 0.96 | DRD2 (0.43) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL7883032 | 0.93 | CCR1 (0.48) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL7887491 | 0.90 | HTR1A (0.44) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8396403 | 0.89 | MEN1 (0.49) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8400183 | 0.88 | DRD2 (0.43) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8395683 | 0.88 | CCR1 (0.43) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8400527 | 0.87 | HTR1A (0.50) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8398976 | 0.86 | DRD2 (0.53) | HTR1ADRD2DRD3DRD4SLC6A4 | |
| SCHEMBL8400226 | 0.85 | HTR1A (0.62) | HTR1ASLC6A4 | |
| Oxalic Acid SCHEMBL8400503 | 0.85 | DRD2 (0.49) | HTR1ADRD2DRD3DRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |