Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 16/20 | 0.53 |
| ▸ | ATF1 | P18846 | 15/20 | 0.53 |
| ▸ | JUN | P05412 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | XPO1 | O14980 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473934 | 0.85 | ATF1 (0.62) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL19282905 | 0.81 | NFKB1 (0.43) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL30617280 | 0.81 | KDM4E (0.71) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL1549128 | 0.81 | KDM4E (0.71) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL8518174 | 0.80 | NFKB1 (0.62) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL8722111 | 0.79 | NFKB1 (0.60) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL79014 | 0.78 | NFKB1 (0.60) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL480176 | 0.78 | XPO1 (0.62) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL17315283 | 0.76 | NFKB1 (0.58) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL9564861 | 0.76 | NFKB1 (0.58) | NFKB1ATF1JUNNFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |