Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 0.60 |
| ▸ | JUN | P05412 | 5/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.60 |
| ▸ | RELA | Q04206 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 7/20 | 0.38 |
| ▸ | ATF1 | P18846 | 2/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475927 | 0.87 | MAPT (0.60) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8396932 | 0.83 | KDM4E (0.70) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8398500 | 0.79 | NFKB1 (0.53) | NFKB1JUNNFKB2RELAKDM4E | |
| SCHEMBL8891103 | 0.78 | NFKB1 (0.52) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8398281 | 0.77 | MAPT (0.49) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL6477545 | 0.73 | GAA (0.51) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8559321 | 0.73 | MAPT (0.43) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8398384 | 0.73 | JUN (0.59) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL8395161 | 0.73 | KDM4E (0.56) | NFKB1JUNNFKB2RELAMAPT | |
| SCHEMBL16905391 | 0.70 | JUN (0.44) | NFKB1JUNNFKB2RELAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |