Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | FOS | P01100 | 6/20 | 0.64 |
| ▸ | JUN | P05412 | 6/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.64 |
| ▸ | RELA | Q04206 | 6/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914410 | 0.89 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11158474 | 0.88 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11160276 | 0.86 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL7210795 | 0.85 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL7210767 | 0.85 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8394846 | 0.85 | FOS (0.67) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL12929684 | 0.84 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11164512 | 0.84 | NPSR1 (0.67) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11285512 | 0.84 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL11160403 | 0.83 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |