SCHEMBL8398671

SCHEMBL8398671

CCCCCCCCCc1cc([N+](=O)[O-])ccc1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.49
ALDH1A1 P00352 2/20 0.49
KCNH2 Q12809 2/20 0.48
TP53 P04637 2/20 0.47
TSHR P16473 2/20 0.47
TYR P14679 2/20 0.47
MEN1 O00255 1/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX5 P09917 1/20 0.47
MAPT P10636 1/20 0.47
ALOX15 P16050 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
GPR35 Q9HC97 1/20 0.47
CTSB P07858 1/20 0.47
GAA P10253 2/20 0.46
THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28026694 1.00 TDP1 (0.49) TDP1ALDH1A1KCNH2TP53TSHR
SCHEMBL899648 0.98 ALDH1A1 (0.50) TDP1ALDH1A1KCNH2TP53TSHR
SCHEMBL899647 0.98 ALDH1A1 (0.50) TDP1ALDH1A1KCNH2TP53TSHR
SCHEMBL27556368 0.94 ALDH1A1 (0.51) TDP1ALDH1A1TP53TSHRTYR
SCHEMBL27463698 0.87 SMN1; SMN2 (0.53) ALDH1A1TP53TSHRMAPTHTT
Formaldehyde SCHEMBL27590299 0.84 SMN1; SMN2 (0.50) ALDH1A1TP53TSHRMAPTHTT
SCHEMBL11783489 0.83 KCNH2 (0.49) TDP1ALDH1A1KCNH2TSHRMEN1
SCHEMBL3477025 0.83 KCNH2 (0.49) TDP1ALDH1A1KCNH2TSHRMEN1
SCHEMBL22271648 0.83 ALDH1A1 (0.52) TDP1ALDH1A1KCNH2TSHRMAPT
SCHEMBL4231830 0.82 ALDH1A1 (0.58) TDP1ALDH1A1TP53TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859067-A PREPARING BIS(2-HYDROXY-1-NAPHTHYL)DECANE FROM THE CORRESPONDING DIACID; FORMING ACID DICHLORIDE; TREATING WITH 2-NAPHTHOL; REARRANGEMENT; REDUCTION; INHIBITS ACTION OF ADENOSINE TRIPHOSPHATASE ROUFOGALIS BASIL DON (AU) 1999-01-12 US disclosed
US-5741821-A PHENOLIC ENZYME INHIBITORS THE UNIVERSITY OF SYDNEY (AU) 1998-04-21 US disclosed
EP-0703780-A4 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE UNIV SYDNEY (AU) 1998-01-07 EP disclosed
CN-1124922-A Use of natural products and related synthetic compounds for the treatment of cardiovascular diseases UNIV SYDNEY (AU) 1996-06-19 CN disclosed
EP-0703780-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1996-04-03 EP disclosed
WO-1994028886-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1994-12-22 WO disclosed