Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899648 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TDP1SMN1; SMN2TP53TSHR | |
| SCHEMBL8398671 | 0.98 | TDP1 (0.49) | ALDH1A1TDP1SMN1; SMN2TP53TSHR | |
| SCHEMBL28026694 | 0.98 | TDP1 (0.49) | ALDH1A1TDP1SMN1; SMN2TP53TSHR | |
| SCHEMBL27556368 | 0.95 | ALDH1A1 (0.51) | ALDH1A1TDP1SMN1; SMN2TP53TSHR | |
| SCHEMBL27463698 | 0.89 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2TP53TSHRGPR35 | |
| Formaldehyde SCHEMBL27590299 | 0.86 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2TP53TSHRGPR35 | |
| SCHEMBL22271648 | 0.84 | ALDH1A1 (0.52) | ALDH1A1TDP1TSHRKCNH2MAPT | |
| SCHEMBL4231830 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TDP1SMN1; SMN2TP53TSHR | |
| SCHEMBL6549530 | 0.83 | TDP1 (0.50) | ALDH1A1TDP1TSHRGAATHRB | |
| SCHEMBL18688890 | 0.83 | TYR (0.57) | ALDH1A1TDP1SMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083577-A1 | Poly(Ethylene Oxide) Functionalization | SEEO, INC (US) | 2012-04-05 | — | — | US | claimed |
| US-20210371836-A1 | Methods And Compositions Related To Thioesterase Enzymes | GENOMATICA, INC. | 2021-12-02 | — | — | US | disclosed |
| US-11021695-B2 | Methods and compositions related to thioesterase enzymes | GENOMATICA, INC. (US) | 2021-06-01 | — | — | US | disclosed |
| EP-3564345-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | REG Life Sciences, LLC (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-2382285-B1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | REG LIFE SCIENCES LLC (US) | 2019-05-01 | — | — | EP | disclosed |
| US-20190093089-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | GENOMATICA, INC. | 2019-03-28 | — | — | US | disclosed |
| CN-108118041-A | A kind of phospholipase D mutant, recombination engineering bacteria and its preparation method and application | 华南理工大学 | 2018-06-05 | — | — | CN | disclosed |
| US-9951322-B2 | Methods and compositions related to thioesterase enzymes | REG Life Sciences, LLC (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170292121-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | AGAIN BIO APS (DK) | 2017-10-12 | — | — | US | disclosed |
| US-9587231-B2 | Methods and compositions related to thioesterase enzymes | REG Life Sciences, LLC (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160046914-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | GENOMATICA, INC. | 2016-02-18 | — | — | US | disclosed |
| US-9175234-B2 | Methods and compositions related to thioesterase enzymes | REG Life Sciences, LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20120083577-A1 | Poly(Ethylene Oxide) Functionalization | SEEO, INC (US) | 2012-04-05 | — | — | US | disclosed |
| EP-2382285-A2 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | LS9, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010075483-A2 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | LS9, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100154293-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | AGAIN BIO APS (DK) | 2010-06-24 | — | — | US | disclosed |
| US-4104269-A | Methoxymethoxy protected intermediates for photographic dyes | POLAROID CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |
| US-4035401-A | Intermediates for photographic dyes | POLAROID CORPORATION (US) | 1977-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190093089-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | LYPLA1, LYPLA2, ACOT7 | ALDH1A1 2697/4885TDP1 367/4885SMN1; SMN2 3747/4885 |
| US-11021695-B2 | Methods and compositions related to thioesterase enzymes | LYPLA1, LYPLA2, ACOT7 | ALDH1A1 2697/4885TDP1 367/4885SMN1; SMN2 3747/4885 |
| US-20170292121-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | LYPLA1, LYPLA2, ACOT7 | ALDH1A1 2697/4885TDP1 367/4885SMN1; SMN2 3747/4885 |
| US-20100154293-A1 | METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES | LYPLA1, LYPLA2, ACOT7 | ALDH1A1 2697/4885TDP1 367/4885SMN1; SMN2 3747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.