SCHEMBL8399319

SCHEMBL8399319

O=C(O)c1cnc(O)nc1-c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.49
KMT2A Q03164 7/20 0.49
LMNA P02545 4/20 0.48
ALDH1A1 P00352 3/20 0.48
LDHA P00338 1/20 0.46
MAPT P10636 2/20 0.46
MAPK1 P28482 1/20 0.46
ATM Q13315 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HPGD P15428 2/20 0.45
KDM4E B2RXH2 1/20 0.45
POLB P06746 1/20 0.45
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
DHODH Q02127 2/20 0.42
PDE10A Q9Y233 1/20 0.42
NR4A2 P43354 1/20 0.41
THRB P10828 1/20 0.41
HNF4A P41235 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6016478 0.82 MEN1 (0.69) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL400143 0.81 NTRK1 (0.60) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL30315868 0.81 ADORA1 (0.55) MEN1KMT2ALMNAALDH1A1
SCHEMBL8394975 0.81 JUN (0.55) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL4593201 0.79 ALDH1A1 (0.76) MEN1KMT2ALMNAALDH1A1MAPT
SCHEMBL2080464 0.78 MEN1 (0.49) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL6016650 0.78 MEN1 (0.56) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL6016363 0.78 LMNA (0.46) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL6016481 0.77 ALDH1A1 (0.49) MEN1KMT2ALMNAALDH1A1LDHA
SCHEMBL3442522 0.77 HPGD (0.59) MEN1KMT2ALMNAALDH1A1LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5935966-A COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS SIGNAL PHARMACEUTICALS, INC. (US) 1999-08-10 US disclosed
US-5852028-A Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions SIGNAL PHARMACEUTICALS, INC. (US) 1998-12-22 US disclosed
US-5811428-A ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SIGNAL PHARMACEUTICALS, INC. (US) 1998-09-22 US disclosed
WO-1998038171-A1 PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS SIGNAL PHARMACEUTICALS, INC. (US) 1998-09-03 WO disclosed
EP-0850228-A1 PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS SIGNAL PHARMACEUTICALS, INC. (US) 1998-07-01 EP disclosed
WO-1997009315-A1 PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS SIGNAL PHARMACEUTICALS, INC. (US) 1997-03-13 WO disclosed
WO-1997009325-A1 PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS SIGNAL PHARMACEUTICALS, INC. (US) 1997-03-13 WO disclosed