Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8400228 | 0.93 | LTB4R2 (0.35) | MDM2AKR1B1LTB4R2MAOAMAOB | |
| SCHEMBL8395274 | 0.91 | AKR1B1 (0.37) | AKR1B1TP53AKR1A1 | |
| SCHEMBL8399708 | 0.91 | AKR1B1 (0.35) | AKR1B1LTB4R2CNR2TP53 | |
| SCHEMBL8399247 | 0.91 | AKR1B1 (0.32) | HDAC6AKR1B1AKR1A1 | |
| SCHEMBL8399615 | 0.90 | USP5 (0.35) | HDAC6AKR1B1TP53 | |
| SCHEMBL8399483 | 0.88 | HDAC6 (0.39) | HDAC6LTB4R2 | |
| SCHEMBL8982219 | 0.88 | STK17B (0.32) | AKR1B1 | |
| SCHEMBL8399251 | 0.88 | TSHR (0.40) | AKR1B1LTB4R2TP53AKR1A1 | |
| SCHEMBL8400120 | 0.88 | LTB4R2 (0.37) | AKR1B1LTB4R2TP53 | |
| SCHEMBL8398960 | 0.87 | SMN1; SMN2 (0.41) | CNR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647636-B1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | SENJU PHARMA CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| US-5532257-A | ENZYME INHIBITOR | SENJU PHARMACEUTICAL CO., LTD (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0647636-A1 | BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 1995-04-12 | — | — | EP | disclosed |