Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921290 | 0.80 | MAPT (0.44) | ALDH1A1NPC1MAPTCRBNDDB1 | |
| SCHEMBL8488183 | 0.77 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8488193 | 0.77 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8488189 | 0.77 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8399413 | 0.77 | CRBN (0.41) | NPC1RAB9AKMT2ACRBNDDB1 | |
| SCHEMBL8402094 | 0.77 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL13090985 | 0.77 | BRD4 (0.43) | RAB9AMAPTKMT2ASMN1; SMN2CRBN | |
| SCHEMBL8402252 | 0.77 | MMP12 (0.41) | ALDH1A1RAB9ASMN1; SMN2CRBNDDB1 | |
| SCHEMBL8400995 | 0.77 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8402142 | 0.74 | THRB (0.50) | CRBNDDB1MMP12BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0711283-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003281-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-02-02 | — | — | WO | disclosed |