Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30451378 | 0.89 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL24252913 | 0.89 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL25244529 | 0.89 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL15674609 | 0.88 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL29684781 | 0.87 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL1371009 | 0.85 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL15674547 | 0.81 | PKM (0.49) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL14785415 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1LMNAMAPTHTT | |
| SCHEMBL3199685 | 0.80 | GAA (0.55) | KDM4ESMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL1303864 | 0.79 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917181-B1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-9409893-B2 | Heteroaryl derivatives and uses thereof | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2917181-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | Jacobus Pharmaceutical Company, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014074775-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2014-05-15 | — | — | WO | disclosed |
| US-20140135320-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2014-05-15 | — | — | US | disclosed |
| US-5929107-A | INHIBITORS OF ACYL-COA:CHOLESTEROL ACYLTRANSFERASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| EP-0585913-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5700810-A | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| US-5492929-A | ENZYME INHIBITORS, ANTICHOLESTEROL AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-20 | — | — | US | disclosed |
| US-5482967-A | LOWERING CHOLESTEROL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| EP-0602598-A1 | 3-Phenylindolyl-, -benzofuranyl- and -benzothienyl- alkylcarboxanilides, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0585913-A2 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135320-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | ABCC1, CYP3A43, ABCB1 | KDM4E 2224/4885SMN1; SMN2 4777/4885ALDH1A1 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.