Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747512 | 0.92 | KMT2A (0.50) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1433076 | 0.86 | MAPT (0.49) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20313968 | 0.86 | MTNR1A (0.54) | CKS1BSKP1SKP2TSHRIDO1 | |
| SCHEMBL9546435 | 0.86 | KMT2A (0.46) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15283620 | 0.82 | CKS1B (0.50) | GAAMEN1KMT2ASMN1; SMN2CKS1B | |
| SCHEMBL5769720 | 0.82 | CKS1B (0.43) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15581649 | 0.81 | MAPT (0.45) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9180518 | 0.81 | KMT2A (0.72) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8978503 | 0.79 | MTNR1A (0.68) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3068694 | 0.79 | SMN1; SMN2 (0.47) | MAPTMEN1KMT2ASMN1; SMN2CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998415-A | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors | MERCK SHARP & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
| WO-1997016446-A1 | BICYCLIC HETEROARYL-ALKYLENE-(HOMO)PIPERAZINONES AND THIONE ANALOGUES THEREOF, THEIR PREPARATION AND THEIR USE AS SELECTIVE AGONISTS OF 5-HT1-LIKE RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-09 | — | — | WO | disclosed |