SCHEMBL8400256

SCHEMBL8400256

CC(C)(C)c1ccc2ncnnc2c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 5/20 0.38
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
KCNH2 Q12809 1/20 0.38
LRRK2 Q5S007 1/20 0.37
METAP2 P50579 1/20 0.36
MAPT P10636 2/20 0.34
MEN1 O00255 1/20 0.34
GAA P10253 1/20 0.34
PKM P14618 1/20 0.34
RECQL P46063 1/20 0.34
KMT2A Q03164 1/20 0.34
PDE10A Q9Y233 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
TSHR P16473 1/20 0.33
FYN P06241 2/20 0.33
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22292163 0.92 SCN10A (0.38) SCN10AALDH1A1HPGDALOX15HSD17B10
SCHEMBL25783534 0.77 SCN10A (0.32) SCN10AKCNH2LRRK2PDE10A
SCHEMBL21672220 0.77 ALDH1A1 (0.41) SCN10AALDH1A1HPGDALOX15HSD17B10
SCHEMBL761268 0.77 ALDH1A1 (0.42) SCN10AALDH1A1HPGDALOX15HSD17B10
SCHEMBL407269 0.74 KDM4E (0.44) PKMTSHREGFRGAK
SCHEMBL26795804 0.73 KIF11 (0.31) PDE10AKIF11
SCHEMBL23118240 0.72 SCN10A (0.47) SCN10AALDH1A1HPGDALOX15HSD17B10
SCHEMBL2707266 0.72 SCN10A (0.47) SCN10AALDH1A1HPGDALOX15HSD17B10
SCHEMBL8208335 0.71 EGFR (0.47) ALDH1A1HSD17B10KCNH2MAPTMEN1
SCHEMBL8401811 0.71 PIK3CG (0.47) ALDH1A1HSD17B10TDP1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11700768-B2 Compound and organic light emitting device comprising the same LG CHEM, LTD. (KR) 2023-07-11 US disclosed
US-10730842-B2 Small molecule inhibitors of DYRK1A and uses thereof ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2020-08-04 US disclosed
US-5856325-A REDUCING INFLAMMATION BY INHIBITING PLA2 IN A MAMMAL BOEHRINGER MANNHEIM GMBH (DE) 1999-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10730842-B2 Small molecule inhibitors of DYRK1A and uses thereof DYRK1A, DYRK2, DYRK1B SCN10A 4508/4885ALDH1A1 3779/4885HPGD 3743/4885
US-11700768-B2 Compound and organic light emitting device comprising the same ARL1, ARRB1, CRY1 SCN10A 3441/4885ALDH1A1 1070/4885HPGD 3833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.