SCHEMBL8400526

SCHEMBL8400526

CCCCCCCCCCCCc1cc(Br)c(O)c(Br)c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.49
ALOX5 P09917 6/20 0.49
CYP3A4 P08684 3/20 0.46
TYR P14679 2/20 0.46
TP53 P04637 2/20 0.46
MEN1 O00255 1/20 0.46
MAPT P10636 1/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
PTPN1 P18031 1/20 0.42
LIPG Q9Y5X9 1/20 0.40
ESR1 P03372 2/20 0.39
ADRA2A P08913 2/20 0.39
ADORA3 P0DMS8 2/20 0.39
TACR2 P21452 2/20 0.39
SLC6A2 P23975 2/20 0.39
SLC6A4 P31645 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8401944 1.00 PTGS2 (0.49) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL8400495 0.82 ALOX5 (0.53) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL7614059 0.82 ALOX5 (0.53) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL5138127 0.79 PTGS2 (0.53) PTGS2ALOX5CYP3A4TP53HTT
SCHEMBL3842135 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL2050571 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL351893 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL4225017 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL21508896 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53
SCHEMBL1685341 0.78 ALOX5 (0.47) PTGS2ALOX5CYP3A4TYRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1954805-A Application of resorcin compound for preparing antitumor medicine UNIV ZHONGNAN (CN) 2007-05-02 CN disclosed
US-5859067-A PREPARING BIS(2-HYDROXY-1-NAPHTHYL)DECANE FROM THE CORRESPONDING DIACID; FORMING ACID DICHLORIDE; TREATING WITH 2-NAPHTHOL; REARRANGEMENT; REDUCTION; INHIBITS ACTION OF ADENOSINE TRIPHOSPHATASE ROUFOGALIS BASIL DON (AU) 1999-01-12 US disclosed
US-5741821-A PHENOLIC ENZYME INHIBITORS THE UNIVERSITY OF SYDNEY (AU) 1998-04-21 US disclosed
EP-0703780-A4 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE UNIV SYDNEY (AU) 1998-01-07 EP disclosed
CN-1124922-A Use of natural products and related synthetic compounds for the treatment of cardiovascular diseases UNIV SYDNEY (AU) 1996-06-19 CN disclosed
EP-0703780-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1996-04-03 EP disclosed
WO-1994028886-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1994-12-22 WO disclosed