SCHEMBL8401048

SCHEMBL8401048

CSc1ccc(-c2ccc(C)c(C)c2)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
CYP3A4 P08684 4/20 0.41
TSHR P16473 3/20 0.41
HSD17B10 Q99714 1/20 0.41
MCL1 Q07820 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
TAS1R3 Q7RTX0 2/20 0.38
TAS1R1 Q7RTX1 2/20 0.38
NPC1 O15118 4/20 0.37
RAB9A P51151 3/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PTGS2 P35354 2/20 0.35
PTGS1 P23219 1/20 0.35
HTR7 P34969 1/20 0.35
MAPT P10636 2/20 0.34
NOTUM Q6P988 1/20 0.34
USP2 O75604 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23966962 0.86 MCL1 (0.40) ALDH1A1CYP3A4TSHRMCL1TDP1
SCHEMBL20344255 0.83 HDAC1 (0.41) ALDH1A1CYP3A4TSHRHSD17B10TDP1
SCHEMBL3084322 0.80 ALDH1A1 (0.55) ALDH1A1CYP3A4TSHRMCL1TDP1
SCHEMBL29702110 0.80 ALDH1A1 (0.55) ALDH1A1CYP3A4TSHRMCL1TDP1
Water SCHEMBL9222873 0.77 ALDH1A1 (0.52) ALDH1A1CYP3A4TSHRMCL1TDP1
SCHEMBL5390940 0.77 ALDH1A1 (0.52) ALDH1A1CYP3A4TSHRMCL1TDP1
Lithium SCHEMBL30110458 0.77 ALDH1A1 (0.60) ALDH1A1CYP3A4TSHRMCL1TDP1
SCHEMBL12736357 0.77 ESR1 (0.45) ALDH1A1CYP3A4TSHRHSD17B10TAS1R3
SCHEMBL13906299 0.77 KIF11 (0.48) ALDH1A1HSD17B10NPC1RAB9APTGS2
SCHEMBL21709538 0.75 ALDH1A1 (0.50) ALDH1A1CYP3A4TSHRMCL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120129076-A1 Novel Sulfonic Acid Group-Containing Segmented Block Copolymer and Use Thereof TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-05-24 US disclosed