Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | MAP2 | P11137 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219841 | 0.92 | MCL1 (0.63) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL17718414 | 0.88 | CA1 (0.57) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL19665897 | 0.88 | MCL1 (0.61) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL9220492 | 0.87 | MCL1 (0.65) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL9217459 | 0.84 | PTPN1 (0.50) | MCL1CA1CA2KDM4EHPGD | |
| SCHEMBL8199557 | 0.84 | MCL1 (0.57) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL9218345 | 0.83 | CA1 (0.56) | MCL1CA1CA2KDM4EMEN1 | |
| SCHEMBL4712880 | 0.82 | POLB (0.57) | MCL1CA1CA2KDM4EALDH1A1 | |
| SCHEMBL9173760 | 0.82 | POLB (0.57) | MCL1CA1CA2KDM4EALDH1A1 | |
| SCHEMBL6940805 | 0.82 | MCL1 (0.62) | MCL1CA1CA2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929107-A | INHIBITORS OF ACYL-COA:CHOLESTEROL ACYLTRANSFERASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| US-5492929-A | ENZYME INHIBITORS, ANTICHOLESTEROL AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-20 | — | — | US | disclosed |
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0602598-A1 | 3-Phenylindolyl-, -benzofuranyl- and -benzothienyl- alkylcarboxanilides, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-06-22 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |