SCHEMBL6940805

SCHEMBL6940805

Cc1ccccc1-c1c(C(=O)O)oc2ccc(Cl)cc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 4/20 0.62
KDM4E B2RXH2 7/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPK1 P28482 2/20 0.52
MAP2 P11137 1/20 0.48
MAOA P21397 1/20 0.45
ALDH1A1 P00352 5/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
CASP3 P42574 1/20 0.45
SENP8 Q96LD8 1/20 0.45
SENP7 Q9BQF6 1/20 0.45
SENP6 Q9GZR1 1/20 0.45
HPGD P15428 3/20 0.45
HSD17B10 Q99714 2/20 0.45
KCNH2 Q12809 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TTR P02766 2/20 0.44
CA1 P00915 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8199557 0.86 MCL1 (0.57) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8403484 0.86 KDM4E (0.60) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8189192 0.84 GABRP (0.55) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8784953 0.84 MAOA (0.51) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8196770 0.84 MCL1 (0.54) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL9219884 0.83 MCL1 (0.46) MCL1KDM4EKMT2AMAPK1ALDH1A1
SCHEMBL8401426 0.82 MCL1 (0.61) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8401455 0.81 LMNA (0.47) MCL1KDM4EMAP2MAOAALDH1A1
SCHEMBL8398928 0.81 MCL1 (0.51) MCL1KDM4EMEN1KMT2AMAPK1
SCHEMBL8196778 0.80 MCL1 (0.59) MCL1KDM4EMEN1KMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003513909-A 2003-04-15 JP claimed
EP-1229907-A1 PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 2002-08-14 EP claimed
CN-1310629-A Combined administration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions WARNER LAMBERT CO (US) 2001-08-29 CN claimed
WO-2001034127-A1 PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-05-17 WO claimed
EP-1098662-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2001-05-16 EP claimed
WO-2000004892-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2000-02-03 WO claimed
EP-1229907-A1 PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 2002-08-14 EP disclosed
CN-1310629-A Combined administration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions WARNER LAMBERT CO (US) 2001-08-29 CN disclosed
WO-2001034127-A1 PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-05-17 WO disclosed
EP-1098662-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2001-05-16 EP disclosed
US-RE36832-E AN ANTICHOLESTEROL AGENT TREATING HYPERCHOLESTEROLEMIA NIHON NOHYAKU CO., LTD (JP) 2000-08-22 US disclosed
WO-2000004892-A2 COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS WARNER-LAMBERT COMPANY (US) 2000-02-03 WO disclosed
US-5929107-A INHIBITORS OF ACYL-COA:CHOLESTEROL ACYLTRANSFERASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-27 US disclosed
EP-0613894-B1 N-Heteroaryl-N'-phenylurea derivatives, their production and use NIHON NOHYAKU CO LTD (JP) 1999-05-06 EP disclosed
US-5492929-A ENZYME INHIBITORS, ANTICHOLESTEROL AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-20 US disclosed
US-5464863-A Anticholesterol agents NIHON NOHYAKU CO., LTD. (JP) 1995-11-07 US disclosed
EP-0613894-A1 N-Heteroaryl-N'-phenylurea derivatives, their production and use NIHON NOHYAKU CO., LTD. (JP) 1994-09-07 EP disclosed
EP-0602598-A1 3-Phenylindolyl-, -benzofuranyl- and -benzothienyl- alkylcarboxanilides, their production and use Takeda Chemical Industries, Ltd. (JP) 1994-06-22 EP disclosed