Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610930 | 0.89 | PTPN1 (0.59) | CA1CA2PTPN1KMT2AMEN1 | |
| SCHEMBL9219744 | 0.84 | PTPN1 (0.56) | PTPN1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL9219841 | 0.84 | MCL1 (0.63) | CA1CA2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8401426 | 0.83 | MCL1 (0.61) | CA1CA2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19665897 | 0.83 | MCL1 (0.61) | CA1CA2KMT2AMEN1POLB | |
| SCHEMBL11732206 | 0.80 | PTPN1 (0.85) | CA1CA2PTPN1KMT2ARAB9A | |
| SCHEMBL11673267 | 0.80 | PTPN1 (0.85) | CA1CA2PTPN1KMT2ARAB9A | |
| SCHEMBL9220313 | 0.80 | MCL1 (0.57) | CA1CA2KMT2AMEN1RAB9A | |
| SCHEMBL9210201 | 0.80 | MCL1 (0.57) | CA1CA2KMT2AMEN1RAB9A | |
| SCHEMBL9216643 | 0.79 | PTPN1 (0.56) | CA1CA2PTPN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |