Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006013 | 0.89 | LMNA (0.51) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10463812 | 0.79 | KDM4E (0.48) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4104120 | 0.78 | GSK3B (0.49) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4104116 | 0.78 | GSK3B (0.49) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11004008 | 0.78 | ADORA2A (0.50) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20893062 | 0.78 | RAB9A (0.49) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20893208 | 0.78 | RAB9A (0.49) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11010858 | 0.77 | KDM4E (0.49) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10462335 | 0.76 | CYP1A2 (0.52) | KDM4ELMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7339029 | 0.74 | KDM4E (0.46) | KDM4ELMNARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919799-A | OVERCOMING RESISTANCE TO AN ANTI-NEOPLASTIC AGENT OR AN ENHANCER FOR THE EFFECT OF AN ANTI-NEOPLASTIC AGENT COMPRISING SAID ENHANCER FOR THE EFFECT OF AN ANTI-NEOPLASTIC AGENT | NIKKEN CHEMICALS CO., LTD. (JP) | 1999-07-06 | — | — | US | disclosed |
| EP-0816366-A1 | IMIDAZOTHIAZOLE COMPOUNDS | Nikken Chemicals Company, Limited (JP) | 1998-01-07 | — | — | EP | disclosed |