Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Eptapirone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.54 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.53 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.48 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.48 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.48 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 17/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.63 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.54 |
| ▸ | HRH2 | P25021 | 5/20 | 0.54 |
| ▸ | HTR7 | P34969 | 5/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eptapirone SCHEMBL8402884 | 1.00 | HTR1A (0.83) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| Eptapirone SCHEMBL678195 | 0.91 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL13532712 | 0.89 | HTR1A (0.95) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| Fumaric Acid SCHEMBL8402874 | 0.84 | HTR1A (0.64) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| Fumaric Acid SCHEMBL8402876 | 0.84 | HTR1A (0.64) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL13532713 | 0.80 | HTR1A (0.78) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL8558871 | 0.79 | HTR1A (0.76) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL15042741 | 0.78 | HTR1A (0.75) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL15042737 | 0.78 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DDRD4 | |
| SCHEMBL8402918 | 0.76 | HTR1A (0.71) | HTR1AADRA1AADRA1BADRA1DDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794949-B1 | NOVEL 3,5-DIOXO-(2H,4H)-1,2,4-TRIAZINE DERIVATIVES, THEIR PREPARATION AND USE AS DRUGS | PF MEDICAMENT (FR) | 1998-07-29 | — | — | EP | claimed |
| US-5977106-A | 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives | PIERRE FABRE MEDICAMENT (FR) | 1999-11-02 | — | — | US | disclosed |