Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 5/20 | 0.61 |
| ▸ | HRH2 | P25021 | 5/20 | 0.61 |
| ▸ | HTR7 | P34969 | 5/20 | 0.61 |
| ▸ | HRH1 | P35367 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.61 |
| ▸ | HTR1B | P28222 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | HTR1D | P28221 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | HTR5A | P47898 | 3/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558871 | 0.86 | HTR1A (0.76) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| Eptapirone SCHEMBL678195 | 0.84 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL13532712 | 0.81 | HTR1A (0.95) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL7495396 | 0.78 | HTR1A (0.46) | HTR1AHTR2ADRD2DRD3HTR2C | |
| SCHEMBL8407259 | 0.77 | HTR1A (0.71) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL13532713 | 0.77 | HTR1A (0.78) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| Eptapirone SCHEMBL8402878 | 0.76 | HTR1A (0.83) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| Eptapirone SCHEMBL8402884 | 0.76 | HTR1A (0.83) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL4546508 | 0.76 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DADRA2A | |
| SCHEMBL8558678 | 0.76 | HTR1A (1.00) | HTR1AADRA1AADRA1BADRA1DADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977106-A | 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives | PIERRE FABRE MEDICAMENT (FR) | 1999-11-02 | — | — | US | disclosed |