Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489291 | 0.83 | SORD (0.49) | HTR1ADRD3HTR2AHRH3ACHE | |
| SCHEMBL30229927 | 0.80 | KDM4E (0.50) | HTR1ADRD3HTR2AHRH3ACHE | |
| SCHEMBL7490520 | 0.80 | ACHE (0.47) | HTR1ADRD3HTR2AHRH3ACHE | |
| SCHEMBL28019839 | 0.79 | OGA (0.51) | HRH3ACHEOGA | |
| SCHEMBL30230144 | 0.79 | OGA (0.51) | HRH3ACHEOGA | |
| SCHEMBL8402918 | 0.78 | HTR1A (0.71) | HTR1ADRD3HTR2AHTR2CDRD2 | |
| SCHEMBL7488440 | 0.77 | HTR1A (0.58) | HTR1ADRD3HTR2AHRH3DRD2 | |
| Fumaric Acid SCHEMBL7488578 | 0.76 | HRH3 (0.41) | HTR1ADRD3HTR2AHTR2CHRH3 | |
| Fumaric Acid SCHEMBL7488585 | 0.76 | HRH3 (0.41) | HTR1ADRD3HTR2AHTR2CHRH3 | |
| SCHEMBL7486478 | 0.76 | SIGMAR1 (0.48) | HTR1AHRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |