Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8402057 | 0.90 | CCKBR (0.44) | CCKBROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8398527 | 0.83 | CCKBR (0.48) | CCKBROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8402444 | 0.80 | CCKBR (0.49) | CCKBRMEN1KMT2AL3MBTL1 | |
| SCHEMBL8913293 | 0.78 | CCKBR (0.46) | CCKBRAADATRAB9A | |
| SCHEMBL8402227 | 0.78 | CCKBR (0.46) | CCKBRAADATMEN1KMT2AKDM4C | |
| SCHEMBL8398546 | 0.76 | CCKBR (0.48) | CCKBR | |
| SCHEMBL8399460 | 0.75 | CCKBR (0.38) | CCKBR | |
| SCHEMBL8398534 | 0.75 | CCKBR (0.48) | CCKBROPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8398551 | 0.75 | CYP2C19 (0.41) | CCKBRAADATTSHR | |
| SCHEMBL8399465 | 0.74 | CCKBR (0.43) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |