SCHEMBL8399465

SCHEMBL8399465

Cc1ccc2c(c1)N(CC(N)=O)C(=O)C(N(C(N)=O)c1cccc(-c3nnn[nH]3)c1)CC2CC1CCCCC1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 5/20 0.43
CCKAR P32238 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8403199 0.90 CCKBR (0.42) CCKBR
SCHEMBL8401331 0.88 CCKBR (0.42) CCKBRCCKAR
SCHEMBL8398988 0.85 CCKBR (0.41) CCKBR
SCHEMBL8398505 0.84 CCKBR (0.41) CCKBR
SCHEMBL8398474 0.84 CCKBR (0.34) CCKBR
SCHEMBL8399467 0.81 CCKBR (0.66) CCKBRCCKAR
SCHEMBL8402207 0.79 CCKBR (0.39) CCKBR
SCHEMBL8917130 0.78 CCKBR (0.41) CCKBR
SCHEMBL8399460 0.76 CCKBR (0.38) CCKBRCCKAR
SCHEMBL8403258 0.74 CCKBR (0.44) CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711283-B1 TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS PFIZER (US) 1999-06-16 EP disclosed
US-5618811-A Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists PFIZER INC. (US) 1997-04-08 US disclosed