Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 8/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.56 |
| ▸ | HTR1D | P28221 | 4/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CFB | P00751 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403318 | 0.93 | ADRA2A (0.65) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Fumaric Acid SCHEMBL8900447 | 0.89 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6976298 | 0.80 | ADRA2A (0.82) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL5612323 | 0.72 | ADRA2A (0.55) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL8900457 | 0.72 | ADRA2A (0.42) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL8403302 | 0.70 | ADRA2A (0.72) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL8926989 | 0.70 | ADRA2A (0.52) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6964869 | 0.70 | ADRA2A (0.55) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL8692296 | 0.69 | ADRA2A (0.54) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7207377 | 0.69 | ADRA2A (0.48) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965595-A | SIDE EFFECT REDUCTION; TREATING NASAL CONGESTION AND OTHER ALPHA-2 ADRENORECEPTOR MODULATED DISORDERS, WILL NOT CAUSE HYPERTENSION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| US-5663189-A | RESPIRATORY, EYES, GASTROINTESTINAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-02 | — | — | US | disclosed |