Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.72 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976298 | 0.77 | ADRA2A (0.82) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL8403318 | 0.77 | ADRA2A (0.65) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL7206662 | 0.77 | ADRA2A (0.68) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL29426311 | 0.75 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL8403268 | 0.70 | ADRA2A (0.56) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL1741885 | 0.70 | ADRA2A (0.77) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL29426313 | 0.70 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL8403305 | 0.70 | ADRA2A (0.35) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL7028091 | 0.69 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA1DADRA1B | |
| SCHEMBL8403307 | 0.68 | ADRA2A (0.34) | ADRA2AADRA1AADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965595-A | SIDE EFFECT REDUCTION; TREATING NASAL CONGESTION AND OTHER ALPHA-2 ADRENORECEPTOR MODULATED DISORDERS, WILL NOT CAUSE HYPERTENSION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |