Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.38 |
| ▸ | ESR1 | P03372 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15293604 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDENPP2SRC | |
| SCHEMBL8404114 | 0.78 | PIK3CG (0.60) | ALDH1A1KDM4EMEN1KMT2APIK3CG | |
| SCHEMBL8749320 | 0.78 | NQO2 (0.52) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL3532558 | 0.78 | SRC (0.67) | ALDH1A1KDM4EHPGDENPP2SRC | |
| SCHEMBL14077239 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDENPP2MEN1 | |
| SCHEMBL2368334 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDENPP2MEN1 | |
| SCHEMBL8399923 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL8749540 | 0.74 | TRPA1 (0.44) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL14582918 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDENPP2MEN1 | |
| SCHEMBL6243628 | 0.73 | PDPK1 (0.52) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856325-A | REDUCING INFLAMMATION BY INHIBITING PLA2 IN A MAMMAL | BOEHRINGER MANNHEIM GMBH (DE) | 1999-01-05 | — | — | US | disclosed |
| EP-0675881-B1 | Use of benzotriazines as PLA2-Inhibitors and new benzotriazines | BOEHRINGER MANNHEIM GMBH (DE) | 1997-03-19 | — | — | EP | disclosed |