SCHEMBL8404576

SCHEMBL8404576

Cc1ccc(C)c2c[nH]cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.47
CYP2A6 P11509 3/20 0.40
NOTUM Q6P988 1/20 0.36
TSHR P16473 3/20 0.35
ALDH1A1 P00352 2/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ATM Q13315 1/20 0.35
POLB P06746 1/20 0.33
CCR1 P32246 1/20 0.32
CCR5 P51681 1/20 0.32
CCR8 P51685 1/20 0.32
ACHE P22303 1/20 0.32
BRPF1 P55201 1/20 0.30
KMT2A Q03164 2/20 0.30
HMBS P08397 1/20 0.30
OPRK1 P41145 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404578 0.73 TSHR (0.48) CYP1A2CYP2A6TSHRALDH1A1CYP3A4
SCHEMBL15761048 0.73 CYP2A6 (0.52) CYP1A2CYP2A6NOTUMTSHRALDH1A1
SCHEMBL149977 0.70
SCHEMBL1484266 0.70 CCR1 (0.46) TSHRALDH1A1HPGDHSD17B10L3MBTL1
SCHEMBL31001023 0.67 CYP1A2 (0.56) CYP1A2CYP2A6TSHRALDH1A1CYP3A4
SCHEMBL16276754 0.65 ADORA2A (0.33) ALDH1A1
SCHEMBL161370 0.65 CYP1A2 (1.00) CYP1A2CYP2A6TSHRALDH1A1CYP3A4
SCHEMBL601246 0.65 CYP1A2 (0.53) CYP1A2CYP2A6TSHRALDH1A1CYP3A4
SCHEMBL31057998 0.62 ALDH1A1 (0.40) CYP1A2CYP2A6TSHRALDH1A1CYP3A4
SCHEMBL1864447 0.62 ALDH1A1 (0.40) CYP1A2CYP2A6TSHRALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114920911-A Method for producing polyisothianaphthene-based conductive polymer 昭和电工株式会社 2022-08-19 CN disclosed
CN-110121516-B Method for producing polyisothianaphthene-based conductive polymer 昭和电工株式会社 2022-07-01 CN disclosed
US-11183340-B2 Method for manufacturing solid electrolytic capacitor SHOWA DENKO K.K. (JP) 2021-11-23 US disclosed
US-11136432-B2 Method for producing polyisothianaphthene-based electroconductive polymer SHOWA DENKO K.K. (JP) 2021-10-05 US disclosed
CN-110121757-B Method for manufacturing solid electrolytic capacitor 昭和电工株式会社 2021-09-14 CN disclosed
US-20200090874-A1 METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR SHOWA DENKO K.K. (JP) 2020-03-19 US disclosed
US-20190345287-A1 METHOD FOR PRODUCING POLYISOTHIANAPHTHENE-BASED ELECTROCONDUCTIVE POLYMER SHOWA DENKO K.K. (JP) 2019-11-14 US disclosed
EP-3564290-A1 METHOD FOR PRODUCING POLYISOTHIANAPHTHENE ELECTROCONDUCTIVE POLYMER Showa Denko K.K. (JP) 2019-11-06 EP disclosed
EP-3564976-A1 METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR Showa Denko K.K. (JP) 2019-11-06 EP disclosed
US-9527828-B2 Method for expanding hematopoietic stem cells using heterocyclic compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-12-27 US disclosed
US-20130245255-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-09-19 US disclosed
US-20130245255-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-09-19 US disclosed
US-20120220790-A1 CYCLOPARA (HETERO) ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME KYOTO UNIVERSITY (JP) 2012-08-30 US disclosed
US-20120220790-A1 CYCLOPARA (HETERO) ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME KYOTO UNIVERSITY (JP) 2012-08-30 US disclosed
EP-2484656-A1 CYCLOPARA(HETERO)ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME Kyoto University (JP) 2012-08-08 EP disclosed
US-20120128640-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2012-05-24 US disclosed
US-20120128640-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2012-05-24 US disclosed
US-20100266556-A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2010-10-21 US disclosed
US-20100266556-A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND NISSAN CHEMICAL INDUSTRIES LTD. (JP) 2010-10-21 US disclosed
EP-2218716-A1 METHOD FOR AMPLIFYING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND Nissan Chemical Industries, Ltd. (JP) 2010-08-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130245255-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS HCLS1, RUNX1, RCC1 CYP1A2 2162/4885CYP2A6 2056/4885NOTUM 4879/4885
US-20120128640-A1 HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS HCLS1, RUNX1, RCC1 CYP1A2 2162/4885CYP2A6 2056/4885NOTUM 4879/4885
US-20100266556-A1 METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND HCLS1, RUNX1, ACIN1 CYP1A2 2808/4885CYP2A6 2755/4885NOTUM 4883/4885
US-20120220790-A1 CYCLOPARA (HETERO) ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME AHR, AR, CYP2A13 CYP1A2 8/4885CYP2A6 50/4885NOTUM 2794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.