Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407924 | 0.82 | HPGD (0.54) | KMT2AALDH1A1MEN1KDM4ETSHR | |
| SCHEMBL8407994 | 0.75 | ADORA3 (0.47) | KMT2AALDH1A1MEN1L3MBTL1KDM4E | |
| SCHEMBL8405232 | 0.73 | ADORA2A (0.46) | KMT2AMEN1MAPTPOLBNFKB1 | |
| SCHEMBL12371703 | 0.71 | JAK2 (0.44) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL13732376 | 0.71 | GAA (0.46) | KMT2AALDH1A1MEN1L3MBTL1KDM4E | |
| SCHEMBL12371755 | 0.69 | ADORA2A (0.46) | KMT2AALDH1A1MEN1JAK2JAK3 | |
| SCHEMBL12371770 | 0.69 | JAK2 (0.43) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL8404996 | 0.69 | PDE4A (0.51) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL12371744 | 0.68 | JAK2 (0.42) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL12371796 | 0.68 | JAK2 (0.42) | KMT2AALDH1A1MEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673938-B1 | Purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1999-07-07 | — | — | EP | disclosed |
| US-5658918-A | INHIBITING NASAL MUCOUS SECRETION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0673938-A2 | Novel purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |