Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405232 | 0.84 | ADORA2A (0.46) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8407994 | 0.77 | ADORA3 (0.47) | ALDH1A1MEN1KMT2AADORA2BADORA3 | |
| SCHEMBL8407814 | 0.76 | GAA (0.47) | ADORA2AMEN1KMT2AADORA2BADORA3 | |
| SCHEMBL8407924 | 0.73 | HPGD (0.54) | ALDH1A1MEN1KMT2ABRD4ADORA3 | |
| SCHEMBL11234998 | 0.70 | ALDH1A1 (0.52) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4191402 | 0.70 | PDE4A (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8407844 | 0.69 | POLB (0.44) | ADORA2B | |
| SCHEMBL8405032 | 0.69 | KMT2A (0.46) | ALDH1A1MEN1KMT2ATSHRCASP1 | |
| SCHEMBL7602847 | 0.68 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL14560539 | 0.67 | ALDH1A1 (0.73) | ADORA2AALDH1A1ADORA2BADORA3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673938-B1 | Purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1999-07-07 | — | — | EP | disclosed |
| US-5658918-A | INHIBITING NASAL MUCOUS SECRETION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0673938-A2 | Novel purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |