Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.49 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.49 |
| ▸ | KLK3 | P07288 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11589724 | 0.86 | NR1H2 (0.61) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL11589058 | 0.82 | NR1H2 (0.60) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL1460117 | 0.81 | PPARA (0.50) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL1459030 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL11588467 | 0.80 | NR1H2 (0.72) | ALDH1A1TP53SMN1; SMN2HSD17B10LMNA | |
| SCHEMBL16202035 | 0.80 | NR1H3 (0.71) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL11592259 | 0.79 | NR1H2 (0.60) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL23153517 | 0.76 | F12 (0.51) | ALDH1A1MAPTSMN1; SMN2HSD17B10LMNA | |
| Fepitrizol SCHEMBL2107850 | 0.76 | USP1 (0.47) | ALDH1A1MAPTSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL14736530 | 0.75 | PDE10A (0.48) | ALDH1A1MAPTTP53SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36374-E | 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists | H. LUNDBECK, A/S (DK) | 1999-11-02 | — | — | US | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |