Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407506 | 0.79 | KDM4E (0.49) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL8407627 | 0.79 | HTR7 (0.41) | DRD2HTR7DRD4 | |
| SCHEMBL12668144 | 0.73 | ALDH1A1 (0.56) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL8406463 | 0.72 | DPP4 (0.40) | DRD2HTR2A | |
| SCHEMBL30607591 | 0.72 | ALDH1A1 (0.64) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL2076150 | 0.72 | ALDH1A1 (0.64) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL10414446 | 0.72 | DRD2 (0.73) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL12670251 | 0.71 | DRD2 (0.64) | DRD2HTR2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL8235906 | 0.69 | KDM4E (0.69) | DRD2HTR2AALDH1A1MAPTHSD11B1 | |
| SCHEMBL6702628 | 0.68 | KDM4E (0.59) | DRD2HTR2AALDH1A1MAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883094-A | Benzimidazolone derivatives with central dopaminergic activity | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |