SCHEMBL8407144

SCHEMBL8407144

C[C@@]12CCC[C@H]1[C@@H]1CC[C@H]3NC(=O)C=C(CO)[C@]3(C)[C@H]1CC2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.41
MBOAT4 Q96T53 3/20 0.40
NR1I3 Q14994 1/20 0.37
GRIN1 Q05586 3/20 0.35
GRIN2B Q13224 3/20 0.35
CDK5 Q00535 1/20 0.34
CDK5R1 Q15078 1/20 0.34
LMNA P02545 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
ABCC4 O15439 1/20 0.34
ABCB11 O95342 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
CHRM1 P11229 1/20 0.34
HSD3B1 P14060 1/20 0.34
SRD5A1 P18405 1/20 0.34
NFKB1 P19838 1/20 0.34
MAPK1 P28482 1/20 0.34
SRD5A2 P31213 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5109018 0.83 CYP19A1 (0.44) CYP19A1MBOAT4NR1I3GRIN1GRIN2B
SCHEMBL4807027 0.82 CYP19A1 (0.41) CYP19A1MBOAT4NR1I3GRIN1GRIN2B
SCHEMBL7643432 0.82 CYP19A1 (0.41) CYP19A1MBOAT4NR1I3GRIN1GRIN2B
SCHEMBL9318599 0.79 CYP19A1 (0.39) CYP19A1MBOAT4NR1I3GRIN1GRIN2B
SCHEMBL11410578 0.79 CYP19A1 (0.38) CYP19A1MBOAT4GRIN1GRIN2BLMNA
SCHEMBL8536969 0.78 CYP19A1 (0.34) CYP19A1MBOAT4GRIN1GRIN2BSRD5A1
SCHEMBL9618179 0.77 SRD5A1 (0.42) CYP19A1MBOAT4GRIN1GRIN2BSRD5A1
SCHEMBL5580929 0.76 CYP19A1 (0.35) CYP19A1MBOAT4GRIN1GRIN2BLMNA
SCHEMBL8540072 0.76 CYP19A1 (0.32) CYP19A1MBOAT4GRIN1GRIN2BSRD5A1
SCHEMBL9543225 0.74 SRD5A1 (0.38) CYP19A1MBOAT4SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994362-A ADMINISTERING FINASTERIDE AND CASODEX MERCK & CO., INC. (US) 1999-11-30 US disclosed
US-5753641-A SYNERGISTIC THERAPY COMPRISING FINASTERIDE AND TERAZOSIN DRUGS MERCK & CO., INC. (US) 1998-05-19 US disclosed
US-5693809-A PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER MERCK & CO., INC. (US) 1997-12-02 US disclosed
WO-1993023039-A1 SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed
WO-1992018132-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA COMTAINING A 5 ALPHA-REDUCTASE INHIBITOR MERCK & CO., INC. (US) 1992-10-29 WO disclosed
WO-1992016213-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO., INC. (US) 1992-10-01 WO disclosed
WO-1992016233-A1 PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN MERCK & CO., INC. (US) 1992-10-01 WO disclosed
US-5098908-A 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors MERCK & CO., INC. (US) 1992-03-24 US disclosed
EP-0462661-A2 Novel 17beta-hydroxybenzoyl-4-aza-5alpha-androst-1-en-3-ones as testosterone reductase inhibitors MERCK & CO. INC. (US) 1991-12-27 EP disclosed