Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407494 | 0.69 | MEN1 (0.45) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL8403277 | 0.66 | ALDH1A1 (0.43) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL6336167 | 0.66 | ALDH1A1 (0.46) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL2105183 | 0.65 | TSHR (0.61) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL27689229 | 0.65 | HTR1D (0.44) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL7484667 | 0.65 | ALDH1A1 (0.42) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL212845 | 0.64 | CYP19A1 (0.81) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL10516379 | 0.64 | ALDH1A1 (0.35) | ALDH1A1TSHRTDP1MEN1KMT2A | |
| SCHEMBL8440730 | 0.63 | TSHR (0.58) | ALDH1A1TSHRTDP1GPR35CYP3A4 | |
| SCHEMBL6378439 | 0.63 | TSHR (0.58) | ALDH1A1TSHRTDP1GPR35CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965595-A | SIDE EFFECT REDUCTION; TREATING NASAL CONGESTION AND OTHER ALPHA-2 ADRENORECEPTOR MODULATED DISORDERS, WILL NOT CAUSE HYPERTENSION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| US-5663189-A | RESPIRATORY, EYES, GASTROINTESTINAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-02 | — | — | US | disclosed |