Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407494 | 0.86 | MEN1 (0.45) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL26250411 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TXNRD1TXNRD3TXNRD2MAPT | |
| SCHEMBL26624965 | 0.79 | MEN1 (0.47) | ALDH1A1TSHRTXNRD1TXNRD3TXNRD2 | |
| SCHEMBL2087092 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPTMEN1KMT2A | |
| SCHEMBL9724874 | 0.75 | TXNRD1 (0.49) | ALDH1A1TDP1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL17659043 | 0.72 | MAPT (0.50) | ALDH1A1TDP1TSHRTXNRD1TXNRD3 | |
| SCHEMBL17659883 | 0.72 | TXNRD1 (0.50) | ALDH1A1TDP1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL9725006 | 0.71 | ALDH1A1 (0.40) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL7484667 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TDP1TSHRGPR35MAPT | |
| SCHEMBL141303 | 0.71 | MAPT (0.59) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104628910-B | Catalyst for producing polypropylene with high isotacticity and preparation method thereof | 中国石油天然气股份有限公司 | 2017-02-08 | — | — | CN | claimed |
| CN-104628910-A | Catalyst for producing polypropylene with high isotacticity and preparation method thereof | PETROCHINA CO LTD | 2015-05-20 | — | — | CN | claimed |
| US-11639355-B2 | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| CN-104628910-B | Catalyst for producing polypropylene with high isotacticity and preparation method thereof | 中国石油天然气股份有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-104628910-A | Catalyst for producing polypropylene with high isotacticity and preparation method thereof | PETROCHINA CO LTD | 2015-05-20 | — | — | CN | disclosed |
| US-5965595-A | SIDE EFFECT REDUCTION; TREATING NASAL CONGESTION AND OTHER ALPHA-2 ADRENORECEPTOR MODULATED DISORDERS, WILL NOT CAUSE HYPERTENSION | THE PROCTER & GAMBLE COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| US-5663189-A | RESPIRATORY, EYES, GASTROINTESTINAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639355-B2 | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors | TP53, MDM2, TP53BP1 | ALDH1A1 549/4885TDP1 46/4885TSHR 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.