Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acridine Orange. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.43 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 3/20 | 0.91 |
| ▸ | TERT | O14746 | 2/20 | 0.91 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | APAF1 | O14727 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine Orange SCHEMBL5520688 | 0.98 | TERT (0.87) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL31143792 | 0.95 | TERT (0.91) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29361720 | 0.95 | TERT (1.00) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL297155 | 0.95 | TERT (1.00) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29837411 | 0.93 | TERT (0.87) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL5859403 | 0.93 | TERT (0.87) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL9985168 | 0.93 | TERT (0.87) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL20816123 | 0.93 | TERT (0.95) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29597528 | 0.93 | TERT (0.95) | APPTERTEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL22071 | 0.93 | TERT (0.95) | APPTERTEGFRAPAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259834-B1 | METHOD OF CLASSIFYING LEUCOCYTES BY FLOW CYTOMETRY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-08-12 | — | — | EP | claimed |
| US-4933293-A | IRRADIATION OF BLOOD AND DYE SOLUTION WITH A WAVELENGTH THAT EXCITES FLUORESCENCE; IDENTIFICATION BASED ON INTENSITY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1990-06-12 | — | — | US | claimed |
| EP-0259834-A2 | Method of classifying leucocytes by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-03-16 | — | — | EP | claimed |
| US-20250389663-A1 | MEASUREMENT APPARATUS AND ANALYSIS METHOD | SYSMEX CORP (JP) | 2025-12-25 | — | — | US | disclosed |
| US-12429424-B2 | Measurement apparatus and analysis method | SYSMEX CORPORATION (JP) | 2025-09-30 | — | — | US | disclosed |
| EP-4439042-B1 | METHOD FOR ANALYZING SPECIMEN | SYSMEX CORP (JP) | 2025-07-09 | — | — | EP | disclosed |
| US-20240329049-A1 | METHOD FOR ANALYZING SPECIMEN | SYSMEX CORPORATION (JP) | 2024-10-03 | — | — | US | disclosed |
| EP-4439042-A1 | METHOD FOR ANALYZING SPECIMEN | SYSMEX CORPORATION (JP) | 2024-10-02 | — | — | EP | disclosed |
| US-20230341314-A1 | METHOD FOR CLASSIFYING WHITE BLOOD CELLS INTO SUBPOPULATIONS | SYSMEX CORPORATION (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230296522-A1 | MEASUREMENT APPARATUS AND ANALYSIS METHOD | SYSMEX CORPORATION (JP) | 2023-09-21 | — | — | US | disclosed |
| EP-4246120-A1 | MEASUREMENT DEVICE AND ANALYSIS METHOD | SYSMEX CORPORATION (JP) | 2023-09-20 | — | — | EP | disclosed |
| US-5296378-A | Lysis of erythrocytes in blood by adding staining agents and dyes, flowing through a cytometer and detection by fluorescence the leukocytes | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0259833-B1 | REAGENT AND METHOD FOR CLASSIFYING LEUKOCYTES BY FLOW CYTOMETRY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1993-01-27 | — | — | EP | disclosed |
| US-5175109-A | Optical measurement on fluorochrome stained red blood cells | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-12-29 | — | — | US | disclosed |
| EP-0259834-B1 | METHOD OF CLASSIFYING LEUCOCYTES BY FLOW CYTOMETRY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-08-12 | — | — | EP | disclosed |
| US-4933293-A | IRRADIATION OF BLOOD AND DYE SOLUTION WITH A WAVELENGTH THAT EXCITES FLUORESCENCE; IDENTIFICATION BASED ON INTENSITY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0259833-A2 | Reagent and method for classifying leukocytes by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-03-16 | — | — | EP | disclosed |
| EP-0259834-A2 | Method of classifying leucocytes by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-03-16 | — | — | EP | disclosed |
| US-4146604-A | STAINING WITH MIXTURE OF FLUORESCENT DYES AND SENSITIZERS | BLOCK ENGINEERING, INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4006360-A | Method of discriminating between dyed particles and background fluorescence of the dye | BLOCK ENGINEERING, INC. (US) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250389663-A1 | MEASUREMENT APPARATUS AND ANALYSIS METHOD | MYD88, HCLS1, F3 | CHRM2 4595/4885ACHE 2396/4885SLC6A2 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.