Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acridine Orange. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 2/20 | 0.55 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.44 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.44 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.44 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.44 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.44 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | PDE3B known ✓ | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.41 |
| ▸ | GLA known ✓ | P06280 | 2/20 | 0.39 |
| ▸ | TERT | O14746 | 2/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine Orange SCHEMBL30153753 | 1.00 | TERT (0.95) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL5859399 | 0.98 | TERT (0.91) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29361720 | 0.98 | TERT (1.00) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL297155 | 0.98 | TERT (1.00) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29837411 | 0.96 | TERT (0.87) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL5859403 | 0.96 | TERT (0.87) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL9985168 | 0.96 | TERT (0.87) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL20816123 | 0.95 | TERT (0.95) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL29597528 | 0.95 | TERT (0.95) | TERTAPPEGFRAPAF1ALDH1A1 | |
| Acridine Orange SCHEMBL8408019 | 0.93 | APP (0.91) | TERTAPPEGFRAPAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 37402 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100715-B1 | PARTICLE ANALYSIS METHOD AND PARTICLE ANALYZER | NIHON KOHDEN CORP (JP) | 2026-05-27 | — | — | EP | claimed |
| CN-117447989-B | Supermolecule fluorescent sensing array and detection application thereof to tyrosine kinase inhibitor | GUIZHOU UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| EP-4744677-A1 | DRY EYE DISEASE TREATMENT THROUGH PHOTOSENSITIZER | Universitatea de Medicina, Farmacie, Stiinte si Tehnologie "George Emil Palade" din Targu Mures (RO) | 2026-05-20 | — | — | EP | claimed |
| CN-122070479-A | Ultrasonic indicating device and method for monitoring ultrasonic treatment | JP实验室股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026102332-A1 | NERVE AND TUMOR HOMING AGENTS AND METHODS OF USE THEREOF | Blaze Bioscience, Inc. (US) | 2026-05-15 | — | — | WO | claimed |
| US-20260131004-A1 | METHOD OF TREATMENT OR INHIBITION | QUEENSLAND EYE INST FOUNDATION (AU) | 2026-05-14 | — | — | US | claimed |
| US-20260131002-A1 | METHOD OF TREATMENT | QUEENSLAND EYE INST FOUNDATION (AU) | 2026-05-14 | — | — | US | claimed |
| EP-4737898-A2 | SEPARATION AND ISOLATION OF NUCLEIC ACIDS USING AFFINITY LIGANDS BOUND TO A SOLID SURFACE | EMP Biotech GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12618776-B2 | Multi-fluorescence image acquisition system and method, and application | SHANGHAI RUIYU BIOTECH CO., LTD. (CN) | 2026-05-05 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-4232552-A | THERMOCHROMISM, DISPOSABLE THERMOMETERS | AKZONA INCORPORATED (US) | 1980-11-11 | — | — | US | claimed |
| US-4215102-A | Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues | LEE SIN H | 1980-07-29 | — | — | US | claimed |
| US-4207554-A | Method and apparatus for automated classification and analysis of cells | MED-EL INC. (US) | 1980-06-10 | — | — | US | claimed |
| EP-0008826-A2 | Method and apparatus for counting bacteria in a bacteria-containing suspension, method for fluorescence staining of bacteria, and method for separating bacteria from a sample | Metrofoss K/S (DK) | 1980-03-19 | — | — | EP | claimed |
| EP-0003583-A1 | Compositions for cytochemical investigation, their use and method for the detection of steroid hormone receptors in human tissues | Lee, Sin Hang (US) | 1979-08-22 | — | — | EP | claimed |
| US-4146454-A | EXCITATION, MOBILIZERS, INITIATORS | HABER INSTRUMENTS, INC. (US) | 1979-03-27 | — | — | US | claimed |
| US-4126516-A | LIPHOPHILIC FLUORESCENT MATERIAL | CORNING GLASS WORKS (US) | 1978-11-21 | — | — | US | claimed |
| US-4085006-A | Automatic cell analyzer method | ISOMEDICS, INCORPORATED (US) | 1978-04-18 | — | — | US | claimed |
| US-4075015-A | Light sensitive mass and process for its production | SWISS ALUMINIUM LTD. (CH) | 1978-02-21 | — | — | US | claimed |
| US-4026705-A | EPOXY RESIN, ARYL IODONIUM SALT, CATIONIC DYE | GENERAL ELECTRIC COMPANY (US) | 1977-05-31 | — | — | US | claimed |