Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.59 |
| ▸ | F2 | P00734 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.55 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8410190 | 0.85 | ALDH1A1 (0.54) | LMNATMPRSS6F2ALDH1A1HDAC1 | |
| SCHEMBL12348116 | 0.84 | TMPRSS6 (0.57) | LMNATMPRSS6F2ALDH1A1PKM | |
| SCHEMBL2009291 | 0.83 | ALDH1A1 (0.72) | LMNAALDH1A1TBXA2RFABP4HDAC1 | |
| SCHEMBL8949146 | 0.83 | ALDH1A1 (0.54) | LMNATMPRSS6F2ALDH1A1TBXA2R | |
| SCHEMBL14599610 | 0.83 | ALDH1A1 (0.57) | LMNATMPRSS6F2ALDH1A1TBXA2R | |
| SCHEMBL5541901 | 0.83 | ALDH1A1 (0.57) | LMNATMPRSS6F2ALDH1A1TBXA2R | |
| SCHEMBL14599528 | 0.83 | ALDH1A1 (0.57) | LMNATMPRSS6F2ALDH1A1TBXA2R | |
| SCHEMBL14599613 | 0.83 | ALDH1A1 (0.57) | LMNATMPRSS6F2ALDH1A1TBXA2R | |
| SCHEMBL12348122 | 0.81 | TMPRSS6 (0.58) | TMPRSS6F2ALDH1A1CA1CA2 | |
| SCHEMBL9029932 | 0.79 | TMPRSS6 (0.53) | LMNATMPRSS6F2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |