Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.56 |
| ▸ | F2 | P00734 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599610 | 1.00 | ALDH1A1 (0.57) | ALDH1A1PKMMEN1KMT2ATMPRSS6 | |
| SCHEMBL14599613 | 1.00 | ALDH1A1 (0.57) | ALDH1A1PKMMEN1KMT2ATMPRSS6 | |
| SCHEMBL14599528 | 1.00 | ALDH1A1 (0.57) | ALDH1A1PKMMEN1KMT2ATMPRSS6 | |
| SCHEMBL12348116 | 0.95 | TMPRSS6 (0.57) | ALDH1A1PKMMEN1KMT2ATMPRSS6 | |
| SCHEMBL12348122 | 0.91 | TMPRSS6 (0.58) | ALDH1A1TMPRSS6F2PRSS1PRSS2 | |
| SCHEMBL9029932 | 0.89 | TMPRSS6 (0.53) | ALDH1A1PKMTMPRSS6F2LMNA | |
| SCHEMBL14599604 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TMPRSS6F2KDM4ELMNA | |
| SCHEMBL8409042 | 0.83 | LMNA (0.60) | ALDH1A1PKMTMPRSS6F2LMNA | |
| SCHEMBL14599612 | 0.83 | ALDH1A1 (0.58) | ALDH1A1TMPRSS6F2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL27601325 | 0.80 | TMPRSS6 (0.56) | ALDH1A1TMPRSS6F2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | claimed |
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-08-18 | — | — | US | claimed |
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
| US-7262223-B2 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182118-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | ALDH1A1 2283/4885PKM 2200/4885MEN1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.