Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 6/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408981 | 0.89 | PTGER4 (0.53) | FFAR1AKR1B1PTGER1PTGER4PTGER3 | |
| SCHEMBL27484581 | 0.85 | MAOB (0.48) | HTR1ADRD2MAOBFFAR1BCHE | |
| Fluoride SCHEMBL28325117 | 0.84 | MAOB (0.56) | MAOBFFAR1AKR1B1SGMS2IMPDH2 | |
| SCHEMBL6035133 | 0.81 | FFAR1 (0.48) | MAOBFFAR1AKR1B1PTGER1PTGER4 | |
| SCHEMBL15602827 | 0.80 | SGMS2 (0.52) | HTR1ADRD2MAOBFFAR1SGMS2 | |
| SCHEMBL2507390 | 0.78 | FFAR1 (0.48) | HTR1ADRD2MAOBFFAR1 | |
| SCHEMBL1761232 | 0.78 | MAOB (0.50) | MAOBFFAR1AKR1B1SGMS2IMPDH2 | |
| SCHEMBL450088 | 0.78 | KDM1A (0.50) | HTR1AMAOBSGMS2IMPDH2 | |
| SCHEMBL8409150 | 0.77 | MAOB (0.43) | MAOBFFAR1BCHEAKR1B1PTGER1 | |
| SCHEMBL8409856 | 0.76 | HTR1A (0.57) | HTR1ADRD2MAOBABCB1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |